Vaccines can effectively protect the human body from harmful bacteria, viruses and cell threats. Basic antigens include intact bacteria or viruses, as well as subunits such as polysaccharides or proteins, which can be combined with other proteins or combined with other adjuvants to enhance the immune response. The diversity of vaccine antigen types and the inherent variability of targets pose challenges for vaccine manufacturers. Accelerating the production of vaccines is essential to provide life support for human beings.
Antigens can not only be produced directly from target cells or viruses in vitro but can also be produced indirectly through recombinant expression systems. Current research focuses on the use of cellular genetic modification technology to produce antigens in the body. This genetic modification can be achieved using DNA or RNA.
Types of Vaccines
Each type of vaccine faces specific process development and manufacturing challenges. Therefore, there is no single vaccine manufacturing method. However, some flexible technologies can meet every challenge in the process development process. These customizable technologies can be applied individually, but they can also be combined to design an integrated platform to support rapid process development and guarantee the quality of life protection vaccines, in which closed systems and aseptic processes are essential.
| Type of Vaccine | Typical Process | Antigen |
|---|---|---|
| Nucleic Acid Vaccine | Ferment Chemical synthesis Cell culture | Plasmid DNA (pDNA) Messenger RNA (mRNA) Recombinant vector vaccine |
| Recombinant vaccine | Cell culture | Recombinant protein Recombinant virus |
| Subunit vaccine | Cell culture (mammalian/insect) Fermentation (bacteria/yeast) | Recombinant protein Polysaccharides and peptides Conjugate |
| Bacterial toxoid vaccine | Ferment | Toxoid protein |
| Whole cell vaccine | Mammalian cell culture Microbial cell culture | Live attenuated virus Live Attenuated Bacteria |
| Microbial cell culture Egg-based/mammalian cell culture | Inactivated bacteria Inactivated virus |
Alfa Chemistry's innovative process technology has made important contributions to the success of many vaccine production processes. We continuously strive to improve our solutions throughout the industry to meet your vaccine development and manufacturing challenges. Our scientific team can work with you to create a platform configuration that meets your specific vaccine production needs.
Please contact us now to discuss how Alfa Chemistry can help you get up and running quickly or improve the efficiency of your vaccine production process.