Filtration, separation and purification

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IV Filter Application for Infusion Therapy

The particle issue is still mostly unnoticed. "Consider filtering treatments and medications to decrease particulate matter in critically ill patients that may cause thrombosis, poor microcirculation, and modify immunological response," the Infusion Nursing Association advised.

Patients in intensive care frequently receive a lot of IV infusions. Every day, up to 1 million particles can be administered without an IV in-line filter. Microcirculation problems may be caused by the injected particles, and reduced microvascular flow in important organs might lead to organ dysfunction in ICU patients.

Our IV in-line filter has been shown in laboratory and clinical tests to catch particles in clinical settings, enhance patient prognosis, and shorten ICU stays.

Particles Trapped in An IV Filter

Patients in the intensive care unit (ICU) are thought to be at a higher risk of being exposed to particles from infusion therapy.

  • Drugs and fluids are mostly given intravenously in the ICU.
  • Patients in intensive care units (ICUs) are given a lot of medications and fluids.
  • Drug incompatibility increases the chance of particle formation in ICU patients who must utilize numerous medications through a restricted number of intravenous access points.

Particle contamination of IV solutions can result from a variety of factors, including insufficient medication reconstitution, drug incompatibility reactions during IV therapy, parenteral nutrition combinations, glass in containers/ampoules, plastic containers, or infusion system components.

Particles Trapped in An IV Filter

The Burden Harmful Particles Cause to Patients

No matter how little the particles are, once they enter the circulatory system, they can do injury to the human body. Particle size, shape, number, properties, and charge all have an impact on the effect of injecting particles.

Vascular obstruction, systemic hypercoagulability due to coagulation system activation, microcirculation damage, immunological modulation, and inflammatory reactions are all possible side effects of the injected particles. Furthermore, protein particles produced from therapeutic proteins (such as monoclonal antibody treatment) have the potential to trigger immunogenicity and hypersensitivity reactions.

The Burden Harmful Particles Cause to Patients

What is the total number of particles injected into the patient? The settings of the ICU infusion regimen, the medications tested, the frequency of drug incompatibility, and the particle size counted all play a role in this. Particles less than 100 microns have been classed as invisible in studies. Infusion methods, single medications, parenteral feeding solutions, and drug containers all have particles that are mostly in the sub-visible range. The rule of thumb is that the higher the number, the smaller the granularity.

The IV Filter Clinical Benefits for ICU Patients

Using IV in-line filters has been shown to have clinical benefits in several investigations. IV online filters have been found in a number of human clinical studies to benefit ICU patients by maintaining organ function, reducing the incidence of systemic inflammatory response syndrome (SIRS), and reducing the incidence of postoperative phlebitis in surgical patients.

Researchers and doctors have long been interested in the impact of particles on ICU patients, as well as the impact of particle-retaining IV in-line filters. In this sense, our IV filter has been and will continue to be the driving force.

Our highly qualified technical experts are always available to help you with intravenous filtration and infusion solutions, as well as drug compatibility tests.

Our products and services are for research use only and cannot be used for any clinical purpose.