The tangential flow filter element we provide is a tangential flow filter device containing microporous hollow fiber membranes (HFM). The equipment is very suitable for various biopharmaceutical applications, including bacterial cell concentration, mammalian cell concentration, yeast concentration, and continuous cell culture perfusion. Filters come in a variety of sizes, including capsule and filter element forms. The filter cartridge is designed to be installed in a stainless steel housing for steam in situ (SIP) sterilization and manipulation. The capsule can be provided as a stand-alone filter or as part of a processable, gamma sterilization component. Both capsule and cartridge filters are designed to withstand the stringent requirements of autoclave, SIP, or gamma sterilization.